Why regain weight




















Zhang, Y. Positional cloning of the mouse obese gene and its human homologue. Siiteri, P. Adipose tissue as a source of hormones. The secretory function of adipocytes in the physiology of white adipose tissue. Choi, C. Adipose crosstalk with other cell types in health and disease. Cell Res. Hocking, S. Intrinsic depot-specific differences in the secretome of adipose tissue, preadipocytes, and adipose tissue-derived microvascular endothelial cells.

Strohacker, K. Adaptations of leptin, ghrelin or insulin during weight loss as predictors of weight regain: a review of current literature. Blood profile of proteins and steroid hormones predicts weight change after weight loss with interactions of dietary protein level and glycemic index.

Circulating ACE is a predictor of weight loss maintenance not only in overweight and obese women, but also in men. Effects of weight change on plasma leptin concentrations and energy expenditure. Tamez, M. Adipocyte size and leptin receptor expression in human subcutaneous adipose tissue after Roux-en-Y gastric bypass. Bluher, M. From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century. Metabolism 64 , — Qi, Y. Adiponectin acts in the brain to decrease body weight.

Park, S. Long-term central infusion of adiponectin improves energy and glucose homeostasis by decreasing fat storage and suppressing hepatic gluconeogenesis without changing food intake. Smith, U. Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. Noy, N. Vitamin A in regulation of insulin responsiveness: mini review. Brestoff, J.

Immune regulation of metabolic homeostasis in health and disease. Cell , — Bernstein, K. A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme. McGregor, R. Hilton, C. MicroRNAs in adipose tissue: their role in adipogenesis and obesity. Valenti, M. Role of microRNAs in progenitor cell commitment and osteogenic differentiation in health and disease review.

Zaragosi, L. Chen, S. The miRd-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling. Cell Death Differ. Liu, W. Karbiener, M. MicroRNA family is required for human adipogenesis and drives characteristics of brown adipocytes.

Stem Cells 32 , — MicroRNA and adipogenesis. Belarbi, Y. Fatima, F. Long distance metabolic regulation through adipose-derived circulating exosomal miRNAs: a trail for RNA-based therapies? MicroRNA regulatory networks in human adipose tissue and obesity. Diabetes 61 , — Zhu, L. MiR, an adipogenesis-related microRNA, is involved in adipose tissue inflammation. Cell Biochem. Ortega, F. Surgery-induced weight loss is associated with the downregulation of genes targeted by MicroRNAs in adipose tissue.

Schroeder, M. Hypothalamic miR regulates individual metabolic differences in response to diet-induced weight cycling. Bollepalli, S. Subcutaneous adipose tissue gene expression and DNA methylation respond to both short- and long-term weight loss. Martinez, J. Epigenetics in adipose tissue, obesity, weight loss, and diabetes. Maurizi, G. Adipocytes properties and crosstalk with immune system in obesity-related inflammation.

Capel, F. Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women. Adipose tissue gene expression is differentially regulated with different rates of weight loss in overweight and obese humans.

Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization. Schmitz, J. Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss. Snel, M. Immediate and long-term effects of addition of exercise to a week very low calorie diet on low-grade inflammation in obese, insulin-dependent type 2 diabetic patients. Food Chem. Malisova, L.

Expression of inflammation-related genes in gluteal and abdominal subcutaneous adipose tissue during weight-reducing dietary intervention in obese women. Zou, J. Kong, L. Insulin resistance and inflammation predict kinetic body weight changes in response to dietary weight loss and maintenance in overweight and obese subjects by using a Bayesian network approach.

Wang, H. Regulation of energy balance by inflammation: common theme in physiology and pathology. Immune modulation of brown ing adipose tissue in obesity. Armenise, C. Transcriptome profiling from adipose tissue during a low-calorie diet reveals predictors of weight and glycemic outcomes in obese, nondiabetic subjects. Combining biological and psychosocial baseline variables did not improve prediction of outcome of a very-low-energy diet in a clinic referral population.

Caires, R. Omega-3 fatty acids modulate TRPV4 function through plasma membrane remodeling. Sidossis, L. Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. Shen, W. Tsiloulis, T. No evidence of white adipocyte browning after endurance exercise training in obese men. Norheim, F. The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans. FEBS J. Nakhuda, A.

Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss. Pino, M. Active individuals have high mitochondrial content and oxidative markers in their abdominal subcutaneous adipose tissue. Steig, A. Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain.

Giles, E. Exercise decreases lipogenic gene expression in adipose tissue and alters adipocyte cellularity during weight regain after weight loss. Frontiers Physiol. Bartus, R. Esser, N. Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease. Expert Opin. Drugs 24 , — Poulsen, M.

Resveratrol and inflammation: challenges in translating pre-clinical findings to improved patient outcomes. Acta , — Gleeson, M. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Lancaster, G. The immunomodulating role of exercise in metabolic disease. Trends Immunol. Auerbach, P. Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men.

Kerns, J. Ostendorf, D. Objectively measured physical activity and sedentary behavior in successful weight loss maintainers. Obesity Silver Spring 26 , 53—60 Biochemical, anthropometric and lifestyle factors related with weight maintenance after weight loss secondary to a hypocaloric mediterranean diet.

Kjaer, T. Resveratrol reduces the levels of circulating androgen precursors but has no effect on, testosterone, dihydrotestosterone, PSA levels or prostate volume. A 4-month randomised trial in middle-aged men.

Prostate 75 , — Calder, P. Long-chain fatty acids and inflammation. Shivappa, N. Associations between dietary inflammatory index and inflammatory markers in the Asklepios Study. Designing and developing a literature-derived, population-based dietary inflammatory index. Health Nutr. Ramallal, R. Obesity 25 , — Muhammad, H. Dietary intake after weight loss and the risk of weight regain: macronutrient composition and inflammatory properties of the diet.

Ravussin, E. Obesity Silver Spring 17 , — Aller, E. Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial month results. Johansson, K. Effects of anti-obesity drugs, diet, and exercise on weight-loss maintenance after a very-low-calorie diet or low-calorie diet: a systematic review and meta-analysis of randomized controlled trials.

Effect of sibutramine on weight maintenance after weight loss: a randomised trial. Richelsen, B. Effect of orlistat on weight regain and cardiovascular risk factors following a very-low-energy diet in abdominally obese patients: a 3-year randomized, placebo-controlled study. Diabetes Care 30 , 27—32 Wadden, T. Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study. Vazquez, C. Meal replacement with a low-calorie diet formula in weight loss maintenance after weight loss induction with diet alone.

And know what can contribute to pounds creeping back. Some diets, especially those that restrict entire food groups, are simply not sustainable for the long term plus, they're often unhealthy. As soon as you restrict something, you may find that your body starts to crave it. That can quickly end a diet. An unrealistic exercise plan, say going from very little exercise to seven days a week at the gym, can have a similar effect. While you might lose weight initially, these extreme diet and exercise programs require such drastic changes that you can only follow them for a short period of time.

Plus, you're not learning how to create new, healthy habits that you can employ moving forward. As soon as you start losing weight, your body suddenly wants it all back. It can't tell the difference between intentional weight loss and being struck by famine. It immediately goes into protective mode, lowering your metabolism and stimulating your appetite to preserve fat stores.

On top of that, when you lose weight, your body needs fewer calories to maintain itself. However, your body prompts you to keep eating those calories to fill this "energy gap.

One study found that for every two pounds you lose, your body will try to get you to eat more calories than usual. Another known culprit of weight regain is your relationship with your car, TV, computer, and other assorted electronics that encourage you to sit for hours at a time.

Sitting can actually shut down your metabolism, but it's what we spend most of our time doing, whether for work or leisure. Those who have lost weight successfully often restrict how much TV they watch and look for ways to be active throughout the day, in addition to their regular workouts.

They might use a standing or treadmill desk or take frequent breaks to stand or move during the workday. Aside from avoiding too much sedentary time, intentional exercise is crucial for successful weight loss and maintenance. The American College of Sports Medicine reports that consistent physical activity is essential after weight loss—and the more the better.

Everyone needs a different amount of exercise , depending on a variety of factors including gender, age, fitness level, weight, body composition, and genetics. Experts suggest starting with the following guidelines:.

Remember, especially if you are just starting out, that any form of physical movement is better than nothing. Try not to feel like you are unsuccessful if you don't measure up to recommended standards of physical activity, especially if you're just starting out.

Even walking around the block a few times, a few jumping jacks in place, or a stretch before bedtime can help you feel like you're on the right path, and you will probably feel the physical benefits of those activities sooner than you think. There are no simple solutions, but it's usually easier to prevent the weight from coming back than it is to lose it in the first place or a second time. So working hard on maintaining your loss will pay off. When you lose weight quickly—especially if you change your diet but do not exercise—you not only lose fat, but muscle as well.

That slows your metabolism , which contributes to weight gain. If you want long-term weight loss, you need a long-term lifestyle change , which will include a variety of new skills and habits. That includes how to exercise: What you enjoy, how much you can handle, how to fit it into your schedule, how to stay motivated on a daily basis, and how to make your exercise habit stick.

You'll need to learn how to eat differently: How to monitor your portions and avoid emotional eating, for example. And you may have to deal with other issues that contribute to weight gain, such as stress and lack of sleep. The more weight you lose, the fewer calories your body needs to maintain itself.

Tracking that can help you keep the calorie deficit you need to maintain weight loss. When you calculate how many calories you burn during exercise , make sure to subtract the number of calories you would have burned if you weren't exercising.

For example, if you burned calories during a minute run, subtract the number of calories you would have burned sitting e. While we need to move around a bit to complete the tasks of daily living, in modern life we tend not to move very much.

Thus, for most people, 80 percent of the calories we expend each day are due to RMR. When you lose weight, your RMR should fall a small amount, as you are losing some muscle tissue. But when most of the weight loss is fat, we would expect to see only a small drop in RMR, as fat is not metabolically very active. What is surprising is that relatively large drops in RMR are quite common among individuals who lose body fat through diet or exercise.

Most people cannot fit this activity level into their lifestyle. Metabolic activity is dependent on oxygen delivery to the tissues of the body. This occurs through blood flow. As a result, cardiac output is a primary determinant of metabolic activity. The adult body contains about four to five liters of blood, and all of this blood should circulate throughout the body every minute or so. However, the amount of blood the heart can pump out with each beat is dependent on how much blood is returned to the heart between beats.

The veins in our body are are quite flexible and can expand many times their resting size, and our soft skin also allows lower body volume expansion. As a result, when we are sitting quietly, blood and interstitial fluid the fluid which surrounds all the cells in our body pools in the lower parts of the body. This pooling significantly reduces the amount of fluid returning to the heart, and correspondingly, reduces how much fluid the heart can pump out during each contraction.

This reduces cardiac output, which dictates a reduced RMR. Our research has shown that for typical middle-aged women, cardiac output will drop about 20 percent when sitting quietly.

For individuals who have recently lost weight, the fluid pooling situation can be greater because their skin is now much looser, providing much more space for fluids to pool. This is especially the case for people experiencing rapid weight loss, as their skin has not had time to contract.



0コメント

  • 1000 / 1000